IMMUNOLOGIC ALTERATIONS IN BLADDER TUMORS I

Induced immunologic response to tumors.

A tumoricidal system has been described utilizing a two-step process which, first, specifically alters the antigenic nature of a tumor cell and, second, adds a heterologous cytotoxic anti body without affecting normal cells. The antigenic structure of the tumor cell is altered by the nitrogen mustard, L-phenylalanine mustard, and a specific antibody is made to this mustard by injecting it into ...

Immunologic Control of Tumors by In Vivo

Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.

Arsenic is a well-documented human carcinogen, and contamination with this heavy metal is of global concern, presenting a major issue in environmental health. However, the mechanism by which arsenic induces cancer is unknown, in large part due to the lack of an appropriate animal model. In the present set of experiments, we focused on dimethylarsinic acid (DMA), a major metabolite of arsenic in...

Biology of Human Tumors Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer

Purpose:Genetic analysis of bladder cancer has revealed a number of frequently altered genes, including frequent alterations of the telomerase (TERT) gene promoter, although few altered genes have been functionally evaluated. Our objective is to characterize alterations observed by exome sequencing and sequencing of the TERT promoter, and to examine the functional relevance of histone lysine (K...

P53 alterations in bladder tumors from arsenic and tobacco exposed patients.

Previous studies demonstrated that tobacco and arsenic exposure are risk factors for bladder cancer. A case-case study was conducted to compare p53 mutations in 147 bladder tumors from South American patients by tobacco and arsenic exposure. Information on residential history and lifestyle factors was collected. The prevalence of p53 mutations and protein expression was examined in relation to ...